Lactic acid separation and recovery from fermentation broth by ion-exchange resin: A review

Abstract Lactic acid has become one of the most important chemical substances used in various sectors. Its global market demand significantly increased recent years, with a CAGR 18.7% from 2019 to 2025. Fermentation been considered preferred method for producing high-purity lactic industry over synthesis. However, recovery and separation microbial fermentation media are relatively complicated expensive, especially process relating second-generation (2G) recovery. This article reviews development progress related broth. Various aspects discussed thoroughly, such as mechanism production through fermentation, crucial factors that influence process, conventional advanced methods. review's highlight is by adsorption technique using ion-exchange resins brief focus on potential in-site strategies alongside influenced ion exchange. Apart that, other techniques, neutralization, liquid–liquid extraction, membrane separation, distillation, also thoroughly reviewed.